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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
POLE
All Species:
12.73
Human Site:
T2230
Identified Species:
31.11
UniProt:
Q07864
Number Species:
9
Phosphosite Substitution
Charge Score:
0.22
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q07864
NP_006222.2
2286
261518
T2230
K
C
R
G
V
K
E
T
S
M
P
V
Y
C
S
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_543348
2273
260734
T2217
K
C
R
G
V
K
E
T
N
M
P
V
Y
C
S
Cat
Felis silvestris
Mouse
Mus musculus
Q9WVF7
2283
262009
T2227
K
C
R
G
M
K
E
T
H
M
P
V
Y
C
S
Rat
Rattus norvegicus
NP_001100622
1515
174729
R1467
S
K
T
P
R
Q
G
R
K
L
R
M
R
R
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_001233985
2277
260654
T2221
K
C
H
G
V
K
D
T
H
M
P
L
Y
C
S
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001121995
2284
262166
A2232
K
C
K
G
V
K
E
A
N
M
P
L
Y
C
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_524462
2236
256683
E2184
R
C
S
E
I
K
R
E
N
L
A
E
F
C
T
Honey Bee
Apis mellifera
XP_393171
2183
252634
D2135
E
I
E
F
L
L
I
D
L
L
N
R
K
S
M
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002328167
2221
254636
A2169
R
C
N
Q
V
K
A
A
H
L
S
E
Q
C
S
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P21951
2222
255653
D2173
R
C
H
K
V
K
R
D
Y
M
S
A
H
C
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
90.7
N.A.
90.5
60.7
N.A.
N.A.
83.7
N.A.
80
N.A.
55.2
54.6
N.A.
N.A.
Protein Similarity:
100
N.A.
N.A.
94.6
N.A.
95
63.5
N.A.
N.A.
92
N.A.
90.2
N.A.
71.9
71.5
N.A.
N.A.
P-Site Identity:
100
N.A.
N.A.
93.3
N.A.
86.6
0
N.A.
N.A.
73.3
N.A.
73.3
N.A.
20
0
N.A.
N.A.
P-Site Similarity:
100
N.A.
N.A.
100
N.A.
93.3
26.6
N.A.
N.A.
86.6
N.A.
93.3
N.A.
60
20
N.A.
N.A.
Percent
Protein Identity:
43.5
N.A.
N.A.
N.A.
40.5
N.A.
Protein Similarity:
62.7
N.A.
N.A.
N.A.
60.1
N.A.
P-Site Identity:
33.3
N.A.
N.A.
N.A.
33.3
N.A.
P-Site Similarity:
46.6
N.A.
N.A.
N.A.
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
10
20
0
0
10
10
0
0
0
% A
% Cys:
0
80
0
0
0
0
0
0
0
0
0
0
0
80
0
% C
% Asp:
0
0
0
0
0
0
10
20
0
0
0
0
0
0
0
% D
% Glu:
10
0
10
10
0
0
40
10
0
0
0
20
0
0
0
% E
% Phe:
0
0
0
10
0
0
0
0
0
0
0
0
10
0
0
% F
% Gly:
0
0
0
50
0
0
10
0
0
0
0
0
0
0
0
% G
% His:
0
0
20
0
0
0
0
0
30
0
0
0
10
0
0
% H
% Ile:
0
10
0
0
10
0
10
0
0
0
0
0
0
0
0
% I
% Lys:
50
10
10
10
0
80
0
0
10
0
0
0
10
0
0
% K
% Leu:
0
0
0
0
10
10
0
0
10
40
0
20
0
0
0
% L
% Met:
0
0
0
0
10
0
0
0
0
60
0
10
0
0
10
% M
% Asn:
0
0
10
0
0
0
0
0
30
0
10
0
0
0
0
% N
% Pro:
0
0
0
10
0
0
0
0
0
0
50
0
0
0
10
% P
% Gln:
0
0
0
10
0
10
0
0
0
0
0
0
10
0
0
% Q
% Arg:
30
0
30
0
10
0
20
10
0
0
10
10
10
10
0
% R
% Ser:
10
0
10
0
0
0
0
0
10
0
20
0
0
10
60
% S
% Thr:
0
0
10
0
0
0
0
40
0
0
0
0
0
0
20
% T
% Val:
0
0
0
0
60
0
0
0
0
0
0
30
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
10
0
0
0
50
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _